The ARRB1 Monoclonal Antibody (CAB10742) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced using advanced monoclonal antibody technology, specifically targets beta-arrestin-1, a key protein involved in G protein-coupled receptor (GPCR) signaling and regulation.Beta-arrestin-1 has been implicated in various physiological processes, including cell migration, proliferation, and apoptosis, making it a promising target for therapeutic interventions in diseases such as cancer and cardiovascular disorders. With its high specificity and sensitivity, the Beta-Arrestin-1 Monoclonal Antibody is ideal for use in Western blotting, immunofluorescence, and immunoprecipitation assays to detect and quantify beta-arrestin-1 levels in different cell types and tissues.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
ARRB1 Monoclonal Antibody
SKU:
CAB10742
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Clone Number:
ARC2370
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
Purification Method
Affinity purification
Gene ID
408
RRID
AB_2758192
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using β-arrestin1 Rabbit mAb (CAB10742) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3s.
