The BMAL1 Monoclonal Antibody (CAB4714) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is specifically designed to target BMAL1, a key transcription factor involved in the regulation of circadian rhythm and biological processes. Raised in rabbits, this monoclonal antibody is highly specific and exhibits minimal cross-reactivity, ensuring accurate and reliable results in experiments. It has been rigorously validated for use in various applications, including Western blotting, immunofluorescence, and immunohistochemistry, making it versatile for a wide range of research needs.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
BMAL1 Monoclonal Antibody
SKU:
CAB4714
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC1101
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
HeLa, A-431, SH-SY5Y, Mouse liver, Mouse testis, Mouse brain, Rat liver, Rat brain, Rat eye
Cellular Localization:
Chromatoid Body, Nucleoplasm, Nucleus, Pml Body.
Calculated MW:
69kDa
Observed MW:
78kDa
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. The protein regulates interferon-stimulated gene expression and is an important factor in viral infection, including COVID-19.
Purification Method
Affinity purification
Gene ID
406
RRID
AB_2863329
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using BMAL1 Rabbit mAb (CAB4714) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3s.
