The BOD1 Antibody (PAC019359) is a high-quality polyclonal antibody designed for research involving the BOD1 protein. BOD1 is a crucial regulator of cell division and is involved in maintaining genome stability. This antibody is raised in rabbits, ensuring high reactivity and specificity with human samples.Validated for use in Western blot applications, the BOD1 Antibody binds specifically to the BOD1 protein, allowing for accurate detection and analysis in a variety of cell types. Its versatility makes it an ideal tool for researchers in the fields of cell biology, cancer research, and genomics.
The BOD1 Antibody is essential for understanding the role of BOD1 in cell division and genome stability, making it a valuable asset for studies investigating cancer development, genetic disorders, and mechanisms of cell proliferation. By targeting BOD1, researchers can gain insights into potential therapeutic strategies for diseases related to abnormal cell division and genome instability.
Antibody Name:
BOD1 Antibody (PACO19359)
Antibody SKU:
PACO19359
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human BOD1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19359(BOD1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19359(BOD1 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Bod1, a protein conserved throughout metazoans that associates with a large macromolecular complex and localizes with kinetochores and spindle poles during mitosis. Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule-kinetochore interactions were intact. Releasing Bod1-depleted cells from a monastrol block increases the frequency of syntelic attachments and the number of cells displaying biorientation defects.
Synonyms:
biorientation of chromosomes in cell division 1
UniProt Protein Function:
BOD1: Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Belongs to the BOD1 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q35.2
