Description
system_update_altDatasheet
| Product name | Human FZD7 full length protein-synthetic nanodisc |
| Size: | 10ug |
| Product SKU: | HDFP090 |
| Product Category | Full Length Transmembrane Proteins |
| Target: | FZD7 |
| Uniprot: | O75084 |
| Description: | Human FZD7 full length protein-synthetic nanodisc |
| Molecular Weight: | The human full length FZD7 protein has a MW of 63.4 kDa |
| Protein Family: | Druggable Genome, Transmembrane |
| Protein Pathways: | Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Synonyms: | FzE3 |
| Expression System: | HEK293 |
| Formulation: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Background: | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008] |
| Delivery: | 3-4 weeks |
| Usage | Research use only |
