Description
system_update_altDatasheet
| Product name | Human PTGER4 full length protein-synthetic nanodisc |
| Size: | 10ug |
| Product SKU: | HDFP078 |
| Product Category | Full Length Transmembrane Proteins |
| Target: | PTGER4 |
| Uniprot: | P35408 |
| Description: | Human PTGER4 full length protein-synthetic nanodisc |
| Molecular Weight: | The human full length PTGER4 protein has a MW of 53.1 kDa |
| Protein Family: | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways: | Neuroactive ligand-receptor interaction |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Synonyms: | EP4; EP4R |
| Expression System: | HEK293 |
| Formulation: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Background: | The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008] |
| Delivery: | 3-4 weeks |
| Usage | Research use only |
