The BRD2 Monoclonal Antibody (CAB23166) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody is specifically designed for use in immunohistochemistry and Western blot applications, allowing for precise detection and analysis of BRD2 in various experimental settings.BRD2, a member of the bromodomain and extra-terminal (BET) protein family, plays a key role in chromatin remodeling and transcriptional activation. Its dysregulation has been implicated in various diseases, including cancer and inflammatory disorders. By targeting BRD2 with this monoclonal antibody, researchers can gain valuable insights into its function and potential therapeutic applications.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
BRD2 Monoclonal Antibody
SKU:
CAB23166
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC56992
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatibility complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.
Purification Method
Affinity purification
Gene ID
6046
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from wild type (WT) and BRD2 knockdown (KD) 293T cells using [KD Validated] BRD2 Rabbit mAb (CAB23166) at 1:1000 dilution incubated at room temperature for 1.5 hours. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
