The Calreticulin Polyclonal Antibody (CAB21665) is a valuable tool for researchers studying calreticulin, a multifunctional protein involved in various cellular processes including calcium homeostasis, chaperone activity, and immune response modulation. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.Calreticulin is known to play a role in modulating immune responses, particularly in the context of antigen presentation and T cell activation. Its involvement in immune regulation makes it a promising target for research into cancer immunotherapy, autoimmune diseases, and inflammatory conditions.
By targeting calreticulin, researchers aim to better understand its function in immune cell activation and potentially develop novel therapies that target this protein.With its specific binding to calreticulin, the CAB21665 antibody enables precise detection and analysis of this protein in various cell types, making it an essential tool for studies in immunology, oncology, and other fields where calreticulin's role is of interest. By utilizing this antibody, researchers can gain valuable insights into the mechanisms underlying immune modulation and potentially discover new therapeutic approaches for treating immune-related disorders.
Product Name:
Calreticulin Polyclonal Antibody
SKU:
CAB21665
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-417 of human Calreticulineticulin (NP_004334.1).
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.
Purification Method:
Affinity purification
Gene ID:
811
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Calreticulin Rabbit pAb (CAB21665) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
