Description
CASC3 Antibody (PACO08191)
The CASC3 Polyclonal Antibody (PACO08191) is a reliable tool for researchers studying CASC3, a protein involved in RNA splicing and gene expression regulation. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications. By binding specifically to the CASC3 protein, this antibody enables precise detection and analysis in various cell types, making it an excellent choice for studies in molecular biology and cancer research.
CASC3, also known as cancer susceptibility candidate 3, is a key player in the intricate process of RNA splicing, which is critical for generating functional proteins in cells. Dysregulation of CASC3 has been linked to various diseases, including cancer, making it a promising target for therapeutic interventions. Investigating the role of CASC3 in gene expression and disease development may lead to insights that could aid in the development of novel treatment strategies for cancer and other related disorders.
| Antibody Name: | CASC3 Antibody (PACO08191) |
| Antibody SKU: | PACO08191 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human CASC3 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | cancer susceptibility candidate 3;CASC3;BTZ;MLN51 ; |
| UniProt Protein Function: | CASC3: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer. Belongs to the CASC3 family. |
| UniProt Protein Details: | Protein type:RNA-binding; Translation Chromosomal Location of Human Ortholog: 17q21.1 Cellular Component: perinuclear region of cytoplasm; nuclear speck; cytosol; ribonucleoprotein complex Molecular Function:identical protein binding; protein binding; enzyme binding; ubiquitin protein ligase binding Biological Process: regulation of translation; intracellular mRNA localization; mRNA transport; RNA splicing; mRNA catabolic process, nonsense-mediated decay; gene expression; mRNA processing |
| NCBI Summary: | The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15234 |
| NCBI GenInfo Identifier: | 18266743 |
| NCBI Gene ID: | 22794 |
| NCBI Accession: | O15234.2 |
| UniProt Secondary Accession: | O15234,A8K8R0, |
| UniProt Related Accession: | O15234 |
| Molecular Weight: | 703 |
| NCBI Full Name: | Protein CASC3 |
| NCBI Synonym Full Names: | cancer susceptibility candidate 3 |
| NCBI Official Symbol: | CASC3Â Â |
| NCBI Official Synonym Symbols: | BTZ; MLN51Â Â |
| NCBI Protein Information: | protein CASC3; MLN 51; barentsz; protein barentsz; metastatic lymph node 51; metastatic lymph node gene 51 protein; cancer susceptibility candidate gene 3 protein |
| UniProt Protein Name: | Protein CASC3 |
| UniProt Synonym Protein Names: | Cancer susceptibility candidate gene 3 protein; Metastatic lymph node gene 51 protein; MLN 51; Protein barentsz; Btz |
| Protein Family: | Protein |
| UniProt Gene Name: | CASC3Â Â |
| UniProt Entry Name: | CASC3_HUMAN |
