The CBLN3 Polyclonal Antibody (PACO05032) is a powerful tool for researchers studying CBLN3, a protein involved in synaptic organization and function in the brain. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting CBLN3 in human samples, making it a reliable choice for Western blot analysis.CBLN3, a member of the cerebellin protein family, is known to interact with neurexins and regulate synapse formation and function in the central nervous system. Dysregulation of CBLN3 expression has been implicated in various neurological disorders, making it an important target for research in neuroscience and neurology.
By utilizing the CBLN3 Polyclonal Antibody, researchers can gain valuable insights into the role of CBLN3 in synaptic transmission, plasticity, and neurodevelopment. This antibody is an essential tool for studying the molecular mechanisms underlying brain function and dysfunction, with potential implications for the development of novel therapeutic strategies for neurological diseases.
Antibody Name:
CBLN3 Antibody (PACO05032)
Antibody SKU:
PACO05032
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:40000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the C-terminal region of human Cerebellin 3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CBLN3; Cerebellin-3
UniProt Protein Function:
CBLN3: May be involved in synaptic functions in the CNS.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 14q12Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum; synapse; cell junction
UniProt Protein Details:
NCBI Summary:
Members of the precerebellin family, such as CBLN3, contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal C1q signature domain (see MIM 120550) that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix (Pang et al., 2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009]
