The CBY1 Polyclonal Antibody (PACO64087) is a valuable tool for researchers studying CBY1, a protein involved in cell cycle regulation and development. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the CBY1 protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential component for studies in cell biology and developmental biology.
CBY1, also known as chibby homolog 1, plays a crucial role in regulating the Wnt signaling pathway and influencing cell proliferation and differentiation. Its involvement in these processes makes it a key target for research on various developmental disorders, cancer, and other diseases. By understanding the function of CBY1, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Antibody Name:
CBY1 Antibody (PACO64087)
Antibody SKU:
PACO64087
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein chibby homolog 1 protein (41-126AA)
Western Blot. Positive WB detected in: U87 whole cell lysate, NTERA-2 whole cell lysate, K562 whole cell lysate. All lanes: CBY1 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 15 kDa. Observed band size: 35 kDa.
Background:
Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.
CBY1: Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 22q12Cellular Component: cytosol; nucleoplasm; nucleus; trans-Golgi networkMolecular Function: beta-catenin binding; identical protein binding; protein bindingBiological Process: cardiac muscle cell differentiation; fat cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; protein localization
UniProt Protein Details:
NCBI Summary:
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
