The CCDC106 Polyclonal Antibody (PAC015942) is a valuable tool for researchers studying CCDC106, a protein involved in cellular processes such as cell division and DNA repair. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been rigorously validated for use in Western blot applications. By binding specifically to the CCDC106 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential resource for studies in molecular biology and cancer research.CCDC106, also known as coiled-coil domain-containing protein 106, plays a key role in maintaining genomic stability and regulating cell cycle progression.
Dysregulation of CCDC106 has been linked to the development of cancer and other diseases, highlighting its importance in understanding cellular pathways and disease mechanisms. Research on CCDC106 has the potential to provide insights into novel therapeutic targets for cancer treatment and other related conditions, making the CCDC106 Polyclonal Antibody a valuable asset for scientists exploring these areas of study.
Antibody Name:
CCDC106 Antibody (PACO15942)
Antibody SKU:
PACO15942
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human CCDC106
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15942(CCDC106 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15942(CCDC106 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.
Synonyms:
coiled-coil domain containing 106
UniProt Protein Function:
CCDC106: Promotes the degradation of p53/TP53 protein and inhibits its transactivity.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleusMolecular Function: protein binding
