The CCDC106 Polyclonal Antibody (PACO15943) is a valuable tool for researchers studying the CCDC106 protein, which plays a role in various cellular processes, including cell cycle regulation and DNA damage response. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.CCDC106 is a key player in maintaining genomic stability and ensuring proper cell division, making it essential for normal cell function. Dysregulation of CCDC106 has been associated with cancer development and progression, highlighting its importance in understanding disease mechanisms.
By using the CCDC106 Polyclonal Antibody, researchers can detect and analyze the expression of CCDC106 in different cell types, providing valuable insights into its function and potential impact on disease states. This antibody is a valuable tool for studies in cancer biology, cell biology, and genomics, offering researchers the opportunity to explore the role of CCDC106 in health and disease.
Antibody Name:
CCDC106 Antibody (PACO15943)
Antibody SKU:
PACO15943
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human CCDC106
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15943(CCDC106 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15943(CCDC106 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.
Synonyms:
coiled-coil domain containing 106
UniProt Protein Function:
CCDC106: Promotes the degradation of p53/TP53 protein and inhibits its transactivity.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleusMolecular Function: protein binding
