The CCNL1 Polyclonal Antibody (PAC023690) is a highly specific research tool designed for studying the CCNL1 protein, a cell cycle regulator involved in tumorigenesis and cancer progression. The antibody, produced in rabbits, exhibits strong reactivity towards human samples and is validated for use in Western blot applications. By binding to the CCNL1 protein, this antibody enables accurate detection and analysis in various cell types, making it a valuable asset for research in oncology and cell biology.
CCNL1, also known as Cyclin L1, plays a crucial role in regulating cell cycle progression and gene expression, making it a key target for understanding cancer development and progression. Its involvement in tumorigenesis makes it a promising candidate for therapeutic interventions aimed at targeting cell proliferation and tumor growth. By studying the function of CCNL1, researchers can gain insights into potential treatment strategies for cancer and other related diseases.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Cyclin-L1 antibody.
Western blot analysis of extracts from HeLa cells (Lane 2), A549 cells (Lane 3) and HepG2 cells (Lane 4), using Cyclin-L1 antiobdy. The lane on the left is treated with systhesized peptide.
Western blot analysis of extracts from HepG2 cells, using Cyclin-L1 antibody.
Background:
Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.
Synonyms:
Cyclin-L; CCNL1;
UniProt Protein Function:
CCNL1: cyclin L1, a member of the cyclin family. Associates with the PITSLRE kinase and is involved in pre-mRNA processing.
UniProt Protein Details:
Protein type:Cell cycle regulation; Oncoprotein
Chromosomal Location of Human Ortholog: 3q25.31
Cellular Component: nuclear speck; nucleus
Molecular Function:protein kinase binding
Biological Process: RNA processing; transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of cyclin-dependent protein kinase activity
