The CCRL2 Polyclonal Antibody (PACO08260) is a valuable tool for researchers studying CCRL2, a chemokine receptor involved in immune responses and inflammation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the CCRL2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in immunology and inflammatory diseases.CCRL2 is known to play a crucial role in regulating the recruitment of immune cells to sites of inflammation and infection.
Its involvement in chemokine signaling pathways makes it a key player in the immune response, making it a promising target for research into conditions such as autoimmune disorders, inflammatory diseases, and cancer. Understanding the function of CCRL2 is essential for developing targeted therapies that modulate immune responses and inflammation in these pathological contexts.
CCRL2: Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: CCR chemokine receptor binding; chemokine receptor bindingBiological Process: inflammatory response
UniProt Protein Details:
NCBI Summary:
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
