Description
system_update_altDatasheet
| Product Name: | CD108 monoclonal antibody |
| Product Code: | AGIM0080 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | MEM-150 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgM |
| Host Species: | Mouse |
| Storage: | Store at 4°C. For long-term storage aliquot and sto re at -20°C. Avoid freeze/thaw cycles. |
| Uniprot: | O75326 |
| Background: | CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes througr its receptors plexin C1 and ??1 integrins. |
| UniProt Protein Function: | SEMA7A: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Belongs to the semaphorin family. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 15q22.3-q23 Cellular Component: external side of plasma membrane; extracellular space; membrane; plasma membrane Molecular Function:chemorepellent activity; integrin binding; protein binding; semaphorin receptor binding Biological Process: immune response; integrin-mediated signaling pathway; negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; osteoblast differentiation; positive regulation of axon extension; positive regulation of cell migration; regulation of inflammatory response Disease: Blood Group, John Milton Hagen System |
| NCBI Summary: | This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] |
| UniProt Code: | O75326 |
| NCBI GenInfo Identifier: | 14548264 |
| NCBI Gene ID: | 8482 |
| NCBI Accession: | O75326.1 |
| UniProt Secondary Accession: | O75326,Q1XE81, Q1XE82, Q1XE83, Q1XE84, Q3MIY5, B4DDP7 F5H1S0, |
| UniProt Related Accession: | O75326 |
| Molecular Weight: | 73,364 Da |
| NCBI Full Name: | Semaphorin-7A |
| NCBI Synonym Full Names: | semaphorin 7A (John Milton Hagen blood group) |
| NCBI Official Symbol: | SEMA7AÂ Â |
| NCBI Official Synonym Symbols: | JMH; CD108; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1Â Â |
| NCBI Protein Information: | semaphorin-7A |
| UniProt Protein Name: | Semaphorin-7A |
| UniProt Synonym Protein Names: | CDw108; JMH blood group antigen; John-Milton-Hargen human blood group Ag; Semaphorin-K1; Sema K1; Semaphorin-L; Sema L; CD_antigen: CD108 |
| Protein Family: | Semaphorin |
| UniProt Gene Name: | SEMA7AÂ Â |
| UniProt Entry Name: | SEM7A_HUMAN |
