Description
system_update_altDatasheet
| Product Name: | CD177 monoclonal antibody (FITC) |
| Product Code: | AGIM0094 |
| Size: | 500 µL |
| Reactivity: | Human |
| Clone: | MEM-166 |
| Applications: | Flow Cytometry |
| Conjugate: | FITC |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | Q8N6Q3 |
| Background: | CD177 (NB1/HNA-2a and PRV-1 form) is a GPI-anchored glycoprotein present mainly on neutrophils. Its plasma membrane expression is increased during pregnancy and and inflammation or after GCSF application. Ligand of CD177 has been identified as CD31 (PECAM-1). CD177 participates in neutrophil transmigration and seems to be also a pro-proliferative molecule. The antibodies against CD177 can be involved in neonatal alloimmune neutropenia (NAN). |
| UniProt Protein Function: | CD177: Induced by CSF3 in resting granulocytes. Induced in patients with polycythemia vera (PV) and with essential thrombocythemia (ET). 3 isoforms of the human protein are produced by alternative splicing |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: plasma membrane Biological Process: blood coagulation; leukocyte migration |
| NCBI Summary: | This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q8N6Q3 |
| NCBI GenInfo Identifier: | 91208246 |
| NCBI Gene ID: | 57126 |
| NCBI Accession: | Q8N6Q3.2 |
| UniProt Secondary Accession: | Q8N6Q3,Q711Q2, Q8NCV9, Q96QH1, Q9HDA5, |
| UniProt Related Accession: | Q8N6Q3 |
| Molecular Weight: | 437 |
| NCBI Full Name: | CD177 antigen |
| NCBI Synonym Full Names: | CD177 molecule |
| NCBI Official Symbol: | CD177Â Â |
| NCBI Official Synonym Symbols: | NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GPÂ Â |
| NCBI Protein Information: | CD177 antigen; NB1 glycoprotein; cell surface receptor; human neutrophil alloantigen 2a; polycythemia rubra vera protein 1 |
| UniProt Protein Name: | CD177 antigen |
| UniProt Synonym Protein Names: | Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD_antigen: CD177 |
| Protein Family: | CD177 antigen |
| UniProt Gene Name: | CD177Â Â |
| UniProt Entry Name: | CD177_HUMAN |
