The CD1e Antibody (PACO01948) is a polyclonal antibody designed for research involving the CD1e protein. CD1e is a cell surface glycoprotein that plays a crucial role in lipid antigen presentation to T cells, thereby impacting immune responses. This antibody, generated in rabbits, is highly specific to human CD1e and is validated for use in Western blot and immunohistochemistry applications.With its ability to bind to the CD1e protein, this antibody enables researchers to detect and analyze CD1e expression in various cell types, making it an ideal tool for studies in immunology and infectious diseases.
Understanding the function of CD1e is essential for gaining insights into how lipid antigens are presented to T cells and how this process contributes to immune responses.The CD1e Antibody (PACO01948) is a valuable resource for researchers investigating the role of lipid antigens in immune regulation, autoimmune diseases, and infections. Its specificity and reliability make it a reliable tool for studying the intricate mechanisms of antigen presentation and T cell activation mediated by the CD1e protein.
Antibody Name:
CD1E Antibody
Antibody SKU:
PACO01948
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human CD1E.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]
