Description
system_update_altDatasheet
| Product Name: | CD235a monoclonal antibody (PE) |
| Product Code: | AGIM0374 |
| Size: | 100 µL |
| Reactivity: | Human |
| Clone: | HI264 |
| Applications: | Flow Cytometry |
| Conjugate: | PE |
| Isotype: | IgG2a |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P02724 |
| Background: | CD235a is a transmembrane sialoglycoprotein expressed on erythrocytes and their precursors. GPA is the carrier of blood group M and N specificities which provides the cells with a large mucin-like surface, which minimalizes aggregation between erythrocytes in the circulation.Another function of CD235a is to be an membrane inhibitor of reacitve lysis. CD235a is directed to papain-sensitive epitopes located in the extracellular specific domain of GPA, agglutinating papain-treated cells. CD235a a receptor of Hsa, an Streptococcus adhesin. |
| UniProt Protein Function: | Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). |
| NCBI Summary: | Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02724 |
| NCBI GenInfo Identifier: | 259016238 |
| NCBI Gene ID: | 2993 |
| NCBI Accession: | P02724.2 |
| UniProt Secondary Accession: | P02724,Q9BS51, A8K3E6, B8Q182, B8Q185, |
| UniProt Related Accession: | P02724 |
| Molecular Weight: | 13,000 Da |
| NCBI Full Name: | Glycophorin-A |
| NCBI Synonym Full Names: | glycophorin A (MNS blood group) |
| NCBI Official Symbol: | GYPAÂ Â |
| NCBI Official Synonym Symbols: | MN; GPA; MNS; GPSAT; PAS-2; CD235a; GPErik; HGpMiV; HGpMiXI; HGpSta(C)Â Â |
| NCBI Protein Information: | glycophorin-A |
| UniProt Protein Name: | Glycophorin-A |
| UniProt Synonym Protein Names: | MN sialoglycoprotein; PAS-2; Sialoglycoprotein alpha; CD_antigen: CD235a |
| Protein Family: | Glycophorin |
| UniProt Gene Name: | GYPAÂ Â |
