Description
system_update_altDatasheet
| Product Name: | CD319 monoclonal antibody |
| Product Code: | AGIM0216 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | 162.1 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG2b kappa |
| Host Species: | Mouse |
| Storage: | Store undiluted at 2-8°C. |
| Uniprot: | Q9NQ25 |
| Background: | CD319 is a single-pass type l transmembrane glycoprotein, expressed on NK cells, subsets of mature dendritic cells, activated B cells, and cytotoxic lymphocytes, but not in promyelocytic, B or T cell lines. Expression is highest in the spleen, lymph nodes, and peripheral blood leukocytes, and lowest in bone marrow. Additionally, it is expressed in the small intestine, stomach, appendix, lung, and trachea. CD319 is tyrosine phosphorylated in activated NK cells and is associated with 19 and 39 kD proteins. CD319 has homology with the CD2 family of receptors within the Ig superfamily. Some of the CD2 members stimulate cytotoxicity through the CD319 associated protein. |
