Description
system_update_altDatasheet
| Product Name: | CD66c (CEACAM6) monoclonal antibody (APC) |
| Product Code: | AGIM0185 |
| Size: | 500 µL |
| Reactivity: | Human |
| Clone: | 1H7-4B |
| Applications: | Flow Cytometry |
| Conjugate: | APC |
| Isotype: | IgG1 kappa |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P40199 |
| Background: | CD66c, also known as CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6) is a glycosyl phosphatidyl inositol- (GPI-) anchored glycoprotein. CEACAM and related genes make up the CEA family belonging to the immunoglobulin superfamily. CD66c is involved in cell adhesion. Additionally it serves as pathogen receptor (e.g. Helicobacter pylori, Neisseria, Moraxella, Candida albicans). Immunologically CEACAMs are characterized as members of the CD66 cluster of differentiation. Antibodies against CEACAM6 are commonly used in immunohistochemistry to identify cells expressing the glycoprotein in tissue samples and granulocytes. However, CEACAM6 is also found in serum where it can be used as a tumor marker. In adults CEACAM6 is primarily expressed in epithelia of the gastrointestinal tissue, often together with CEACAM1, CEACAM6 and CEACAM7. In granulocytes CEACAM6 is co-expressed with CEACAM1, CEACAM3 and CEACAM8. Most CEACAM6 antibodies tend to have some degree of cross-reactivity with other CEACAMs but 1H7-4B binds exclusively to CEACAM6. |
| UniProt Protein Function: | CEACAM6: Belongs to the immunoglobulin superfamily. CEA family |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane Molecular Function:protein binding Biological Process: cell-cell signaling; leukocyte migration; signal transduction |
| NCBI Summary: | This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014] |
| UniProt Code: | P40199 |
| NCBI GenInfo Identifier: | 296439410 |
| NCBI Gene ID: | 4680 |
| NCBI Accession: | P40199.3 |
| UniProt Secondary Accession: | P40199,Q13774, Q14920, Q53XP7, |
| UniProt Related Accession: | P40199 |
| Molecular Weight: | 37,195 Da |
| NCBI Full Name: | Carcinoembryonic antigen-related cell adhesion molecule 6 |
| NCBI Synonym Full Names: | carcinoembryonic antigen related cell adhesion molecule 6 |
| NCBI Official Symbol: | CEACAM6Â Â |
| NCBI Official Synonym Symbols: | NCA; CEAL; CD66c  |
| NCBI Protein Information: | carcinoembryonic antigen-related cell adhesion molecule 6 |
| UniProt Protein Name: | Carcinoembryonic antigen-related cell adhesion molecule 6 |
| UniProt Synonym Protein Names: | Non-specific crossreacting antigen; Normal cross-reacting antigen; CD_antigen: CD66c |
| Protein Family: | Carcinoembryonic antigen-related cell adhesion molecule |
| UniProt Gene Name: | CEACAM6Â Â |
| UniProt Entry Name: | CEAM6_HUMAN |
