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PE Anti-Human CD80 Antibody [2D10] (AGEL2469)

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SKU AGEL2469
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG1, κ
Clone 2D10
Conjugation PE
€83 - €325
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Description

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PE Anti-Human CD80 Antibody [2D10]

The PE Anti-Human CD80 Antibody (2D10) is a powerful tool for researchers studying immune responses and cell signaling pathways. CD80, also known as B7-1, is a critical co-stimulatory molecule expressed on antigen-presenting cells that plays a key role in T cell activation and immune regulation. The 2D10 antibody, conjugated with phycoerythrin (PE), allows for the specific detection and visualization of CD80 in human samples using flow cytometry or fluorescence microscopy.This high-quality antibody, meticulously validated for its specificity and sensitivity, offers researchers a reliable means to analyze CD80 expression levels and distribution in different cell types and tissues.

By targeting CD80, researchers can gain insights into immune system function, autoimmune diseases, and potential therapeutic targets for conditions such as cancer or inflammatory disorders. The PE Anti-Human CD80 Antibody (2D10) is a valuable tool for advancing our understanding of immune responses and developing targeted treatments in various research fields.

Product Title:PE Anti-Human CD80 Antibody [2D10]
SKU:AGEL2469
Size:20 Tests, 100 Tests, 200 Tests
Clone No:2D10
Synonyms:T-lymphocyte activation antigen CD80;B7-1; B7; BB1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P33681
Gene ID:941
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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