The CDC42EP4 Polyclonal Antibody (PACO03721) is a valuable tool for researchers studying CDC42EP4, a protein involved in cell signaling and cytoskeletal organization. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to CDC42EP4, the antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and cancer research.
CDC42EP4, also known as Cdc42 effector protein 4, is essential for regulating cell shape, movement, and division by interacting with the small GTPase CDC42. Dysregulation of CDC42EP4 has been implicated in cancer progression and metastasis, making it a potential target for therapeutic interventions. Understanding the function of CDC42EP4 is crucial for developing novel treatments for cancer and other diseases driven by aberrant cell signaling pathways.
Antibody Name:
CDC42EP4 Antibody
Antibody SKU:
PACO03721
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Cdc42EP4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CDC42EP4; BORG4; CEP4; Cdc42 effector protein 4; Binder of Rho GTPases 4
UniProt Protein Function:
CDC42EP4: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. Belongs to the BORG/CEP family.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 17q24-q25Cellular Component: microtubule cytoskeleton; cytoplasm; plasma membrane; endomembrane system; actin cytoskeletonMolecular Function: GTP-Rho bindingBiological Process: regulation of cell shape; positive regulation of pseudopodium formation; positive regulation of actin filament polymerization; Rho protein signal transduction
UniProt Protein Details:
NCBI Summary:
The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]
