The CDCA7 Polyclonal Antibody (PACO05482) is a valuable tool for researchers studying CDCA7, a protein involved in cell cycle regulation and DNA replication. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to CDCA7, this antibody enables accurate detection and analysis of the protein in various cell types, making it an essential component for studies in cell biology and cancer research.CDCA7, also known as cell division cycle-associated protein 7, plays a crucial role in ensuring proper cell division and genomic stability.
Dysregulation of CDCA7 has been linked to cancer development and progression, making it a promising target for anti-cancer therapies. Understanding the function and regulation of CDCA7 is essential for unraveling its role in disease pathogenesis and developing targeted treatments for cancer patients. Researchers can rely on the CDCA7 Polyclonal Antibody (PACO05482) to advance their investigations and contribute to the field of oncology.
Antibody Name:
CDCA7 Antibody (PACO05482)
Antibody SKU:
PACO05482
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human CdcA7.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CDCA7; JPO1; Cell division cycle-associated protein 7; Protein JPO1
UniProt Protein Function:
CDCA7: Participates in MYC-mediated cell transformation; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 2q31Cellular Component: nucleoplasm; cytoplasm; nucleusBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; regulation of cell proliferation
UniProt Protein Details:
NCBI Summary:
This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
