The CDK3 Polyclonal Antibody (PAC017680) is a crucial tool for researchers studying CDK3, a key regulator of cell cycle progression and division. This antibody, produced in rabbits, boasts high reactivity with human samples and has been extensively validated for Western blot applications. By binding specifically to the CDK3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for studies in cell biology and cancer research.
CDK3, a member of the cyclin-dependent kinase family, plays a pivotal role in governing cell cycle checkpoints and promoting cell proliferation. Dysregulation of CDK3 activity has been implicated in numerous diseases, including cancer, making it a promising target for therapeutic interventions. Understanding the molecular mechanisms underlying CDK3 function is critical for the development of novel treatments aimed at disrupting aberrant cell division in cancer cells.
Antibody Name:
CDK3 Antibody (PACO17680)
Antibody SKU:
PACO17680
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human CDK3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO17680(CDK3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.
Synonyms:
cyclin-dependent kinase 3
UniProt Protein Function:
CDK3: a protein kinase of the CDK family. May be involved in cell cycle control. Can phosphorylate histone H1.
UniProt Protein Details:
Protein type:Kinase, protein; Cell cycle regulation; Protein kinase, CMGC; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK/CDK1 subfamily; CDK1 subfamily
Chromosomal Location of Human Ortholog: 17q25.1
Biological Process: cell proliferation; G0 to G1 transition; G1/S transition of mitotic cell cycle; response to DNA damage stimulus
NCBI Summary:
This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
