The Celsr3 Polyclonal Antibody (PACO03585) is an essential tool for researchers studying the role of Celsr3, a cell surface protein involved in cell adhesion and signaling pathways. This antibody, generated in rabbits, exhibits high specificity towards human samples and is validated for use in Western blot applications. By binding to the Celsr3 protein, this antibody enables accurate detection and analysis in various cell types, making it well-suited for investigations in developmental biology and neuroscience.
Celsr3 plays a crucial role in neuronal development, cell migration, and tissue patterning, making it a key player in neurobiology and developmental biology research. Understanding the function of Celsr3 can provide insights into conditions such as neural tube defects, developmental disorders, and neurological diseases. The Celsr3 Polyclonal Antibody is a valuable tool for uncovering the mechanisms underlying these processes and developing potential therapeutic interventions.
Antibody Name:
CELSR3 Antibody
Antibody SKU:
PACO03585
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the N-terminal region of human CDHF11.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CELSR3; CDHF11; EGFL1; FMI1; KIAA0812; MEGF2; Cadherin EGF LAG seven-pass G-type receptor 3; Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-
UniProt Protein Function:
CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21.31Cellular Component: plasma membrane; integral to membraneMolecular Function: G-protein coupled receptor activity; protein binding; calcium ion bindingBiological Process: G-protein coupled receptor protein signaling pathway; regulation of protein localization; neuron migration; axonal fasciculation; cilium biogenesis; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Predicted Molecular Mass: 29.6kDaAccurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions.
NCBI Full Name:
cadherin EGF LAG seven-pass G-type receptor 3
NCBI Synonym Full Names:
cadherin, EGF LAG seven-pass G-type receptor 3
NCBI Official Symbol:
CELSR3Â Â
NCBI Official Synonym Symbols:
FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1Â Â
NCBI Protein Information:
cadherin EGF LAG seven-pass G-type receptor 3
UniProt Protein Name:
Cadherin EGF LAG seven-pass G-type receptor 3
UniProt Synonym Protein Names:
Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains protein 2; Multiple EGF-like domains protein 2
