The Celsr3 Monoclonal Antibody (PACO03586) is a cutting-edge tool for researchers studying Celsr3, a transmembrane protein involved in cell adhesion and signaling pathways. This antibody, produced through a rigorous monoclonal antibody development process, specifically targets the Celsr3 protein, allowing for precise detection and analysis in various cellular contexts.Celsr3, a member of the flamingo cadherin family, plays a critical role in tissue development and organization, particularly in the nervous system. Its involvement in cell polarity and planar cell polarity signaling makes it a key player in processes such as neural tube closure and neural migration.
By studying the function of Celsr3, researchers can gain insights into neurodevelopmental disorders and potential therapeutic targets for neurological conditions.With its high specificity and sensitivity, the Celsr3 Monoclonal Antibody (PACO03586) is an essential tool for researchers investigating the role of Celsr3 in various biological processes. Its validated use in techniques such as immunofluorescence and immunohistochemistry ensures reliable results, making it an invaluable resource for studies in neuroscience, developmental biology, and beyond.
Antibody Name:
CELSR3 Antibody
Antibody SKU:
PACO03586
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human CELSR3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CELSR3; CDHF11; EGFL1; FMI1; KIAA0812; MEGF2; Cadherin EGF LAG seven-pass G-type receptor 3; Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-
UniProt Protein Function:
CELSR3: Receptor that may have an important role in cell/cell signaling during nervous system formation. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCRChromosomal Location of Human Ortholog: 3p21.31Cellular Component: plasma membrane; integral to membraneMolecular Function: G-protein coupled receptor activity; protein binding; calcium ion bindingBiological Process: G-protein coupled receptor protein signaling pathway; regulation of protein localization; neuron migration; axonal fasciculation; cilium biogenesis; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Predicted Molecular Mass: 29.6kDaAccurate Molecular Mass: 29kDa as determined by SDS-PAGE reducing conditions.
NCBI Full Name:
cadherin EGF LAG seven-pass G-type receptor 3
NCBI Synonym Full Names:
cadherin, EGF LAG seven-pass G-type receptor 3
NCBI Official Symbol:
CELSR3Â Â
NCBI Official Synonym Symbols:
FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1Â Â
NCBI Protein Information:
cadherin EGF LAG seven-pass G-type receptor 3
UniProt Protein Name:
Cadherin EGF LAG seven-pass G-type receptor 3
UniProt Synonym Protein Names:
Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains protein 2; Multiple EGF-like domains protein 2
