The CenpO Antibody (PACO16006) is a polyclonal antibody specifically designed for research involving CenpO, a centromere protein essential for cell division and chromosome segregation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in applications such as Western blotting and immunofluorescence.CenpO, a key player in ensuring genome stability during cell division, is a promising target for studying diseases like cancer and developmental disorders. By binding to the CenpO protein, this antibody enables precise detection and analysis of CenpO expression in various cell types, making it a valuable tool for researchers in the fields of cell biology and cancer research.
Understanding the role of CenpO in cellular processes and disease pathology is crucial for developing targeted therapies and diagnostic tools. The CenpO Antibody (PACO16006) provides researchers with a reliable tool for investigating the functions and mechanisms of CenpO, ultimately advancing our understanding of cellular biology and disease progression.
Antibody Name:
CENPO Antibody (PACO16006)
Antibody SKU:
PACO16006
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Fusion protein of human CENPO
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16006(CENPO Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16006(CENPO Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene.
Synonyms:
centromere protein O
UniProt Protein Function:
CENPO: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 2p23.3Cellular Component: cytosol; nucleoplasmMolecular Function: protein bindingBiological Process: DNA replication-independent nucleosome assembly at centromere; sister chromatid cohesion
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
