The CEP152 Polyclonal Antibody (PACO22251) is a valuable tool for researchers studying the centrosomal protein CEP152. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to CEP152, this antibody enables the detection and analysis of this important protein in various cell types.CEP152 is known to play a key role in centrosome biology, specifically in centriole biogenesis and spindle organization during cell division.
Dysregulation of CEP152 has been implicated in various diseases, including microcephaly and ciliopathies. By investigating the function and regulation of CEP152, researchers can gain insights into these disorders and potentially identify new therapeutic targets.With its specificity and reliability, the CEP152 Polyclonal Antibody is an essential tool for studies in cell biology, developmental biology, and genetic diseases. Explore the functions of CEP152 and its implications in human health with this versatile antibody.
Antibody Name:
CEP152 Antibody (PACO22251)
Antibody SKU:
PACO22251
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human CEP152.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human lymph node tissue using CEP152 antibody.
Background:
Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.
Synonyms:
centrosomal protein 152 kDa; centrosomal protein 152kDa; centrosomal protein of 152 kDa;
UniProt Protein Function:
Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
