The CEP250 Polyclonal Antibody (PAC013401) is specifically designed for researchers studying CEP250, a centrosome-associated protein involved in cell division and ciliogenesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the CEP250 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal tool for research in cell biology and developmental biology.CEP250, also known as ninein-like protein, plays a crucial role in centrosome regulation and microtubule organization, essential processes for proper cell division and cilia formation.
Understanding the function of CEP250 is key to unraveling its involvement in diseases such as cancer, ciliopathies, and developmental disorders. By delving into the molecular mechanisms of CEP250, researchers can uncover potential therapeutic targets for these conditions and gain insights into cellular processes governing human health and disease.
centrosomal protein 250kDa;CEP250;C-NAP1;CEP2;CNAP1;MGC88542 ;
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
