The CEP250 Polyclonal Antibody (PACO58500) is a cutting-edge tool designed for research targeting the CEP250 protein, a key player in centrosome organization and cell division. This antibody, produced in rabbits, shows high specificity for human samples and is optimized for Western blot applications. By binding to CEP250, it allows for precise detection and analysis of the protein in a variety of cell types, making it an invaluable asset for studies in cell biology and cancer research.CEP250, also known as centrosomal protein of 250 kDa, is crucial for the proper functioning of centrosomes, the cellular organelles responsible for organizing the mitotic spindle during cell division.
Dysregulation of CEP250 has been linked to abnormal cell division and the development of diseases such as cancer. Research on CEP250 is essential for gaining insights into cell cycle regulation and identifying potential therapeutic targets for cancer treatment. By investigating the role of CEP250, scientists can uncover new strategies for combating cancer and other related disorders.
Antibody Name:
CEP250 Antibody (PACO58500)
Antibody SKU:
PACO58500
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Centrosome-associated protein CEP250 protein (40-293AA)
Immunofluorescent analysis of Hela cells using PACO58500 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Probably plays an important role in centrosome cohesion during interphase.
Synonyms:
Centrosome-associated protein CEP250 (250 kDa centrosomal protein) (Cep250) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Centrosomal protein 2), CEP250, CEP2 CNAP1
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
