The CEP76 Polyclonal Antibody (PACO05385) is a valuable tool for researchers studying CEP76, a protein involved in cell division and centrosome duplication. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blotting.CEP76 is a key player in the regulation of centrosome function, ensuring accurate chromosome segregation during cell division. Dysregulation of CEP76 has been implicated in various diseases, including cancer, where abnormal cell division can lead to tumor formation.
This antibody binds specifically to CEP76, allowing researchers to detect and analyze its expression in different cell types. By studying the role of CEP76 in centrosome duplication and cell division, researchers can gain insights into its potential as a therapeutic target for cancer treatment and other diseases related to cell proliferation. The CEP76 Polyclonal Antibody is a valuable tool for advancing research in cell biology and disease mechanisms.
Antibody Name:
CEP76 Antibody (PACO05385)
Antibody SKU:
PACO05385
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the Internal region of human CEP76.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CEP76; C18orf9; Centrosomal protein of 76 kDa; Cep76
UniProt Protein Function:
CEP76: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication. Belongs to the CEP76 family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 18p11.21Cellular Component: centriole; centrosome; cytosol; protein complexMolecular Function: protein bindingBiological Process: G2/M transition of mitotic cell cycle; mitotic cell cycle; organelle organization and biogenesis; regulation of centriole replication
UniProt Protein Details:
NCBI Summary:
This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
