The CHML Antibody (PACO01418) is a high-quality polyclonal antibody designed for research involving CHML, a protein involved in cell cycle regulation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an ideal tool for studying CHML in various research applications. CHML, also known as choroideremia-like, is a key player in the regulation of cell division and proliferation. It is implicated in processes such as DNA replication and cell growth, making it a valuable target for studies related to cancer, developmental biology, and cell signaling pathways.
This antibody is validated for use in Western blot applications, enabling researchers to detect and analyze CHML protein levels in different cell types and experimental conditions. By understanding the function and regulation of CHML, researchers can gain insights into its role in disease development and potential therapeutic interventions.
Antibody Name:
CHML Antibody
Antibody SKU:
PACO01418
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human REP-2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CHML; REP2; Rab proteins geranylgeranyltransferase component A 2; Choroideraemia-like protein; Rab escort protein 2; REP-2
UniProt Protein Function:
CHML: Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family. Belongs to the Rab GDI family.Chromosomal Location of Human Ortholog: 1q43Cellular Component: cytoplasm; nucleoplasm; Rab-protein geranylgeranyltransferase complexMolecular Function: Rab GTPase bindingBiological Process: protein geranylgeranylation
UniProt Protein Details:
NCBI Summary:
The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]
