The CHMP5 Polyclonal Antibody (PACO08412) is a valuable tool for researchers studying the CHMP5 protein, which is involved in cellular processes such as endosomal sorting and membrane trafficking. This antibody, produced in rabbits, is highly specific and sensitive for detecting CHMP5 in human samples, making it ideal for use in Western blotting and immunohistochemistry applications.CHMP5, also known as Charged Multivesicular Body Protein 5, plays a crucial role in the formation of multivesicular bodies and the degradation of membrane proteins. Dysregulation of CHMP5 has been implicated in various diseases, including cancer and neurodegenerative disorders.
By studying the function and expression of CHMP5, researchers can gain insights into the underlying mechanisms of these diseases and potentially develop targeted therapies.The CHMP5 Polyclonal Antibody is a reliable tool for investigating the role of CHMP5 in cellular pathways and disease processes. Its specificity and sensitivity make it a valuable asset for researchers in the fields of cell biology, molecular biology, and biomedical research.
chromatin modifying protein 5;CHMP5;C9orf83;CGI-34;HSPC177;PNAS-2;SNF7DC2 ;
UniProt Protein Function:
CHMP5: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. Belongs to the SNF7 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: VesicleChromosomal Location of Human Ortholog: 9p13.3Cellular Component: cytosolMolecular Function: protein bindingBiological Process: cell separation during cytokinesis; endosome transport; mitotic metaphase plate congression; non-lytic virus budding; nuclear organization and biogenesis; viral infectious cycle
UniProt Protein Details:
NCBI Summary:
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]
