Based on the information provided in the URL about the CHp2 Antibody (PACO00599), here is a product description:The CHp2 Antibody (PACO00599) is a highly specific and reliable tool for researchers studying the protein CHp2 in various cellular processes. This antibody, produced by Assay Genie, is validated for use in immunofluorescence, immunoprecipitation, and Western blot applications, providing accurate and reproducible results.CHp2 is a critical protein involved in [specific function or pathway], making it a key target for studies in [specific research area]. This antibody binds specifically to CHp2, allowing for precise detection and analysis in a variety of cell types and tissues.
With its high specificity and sensitivity, the CHp2 Antibody (PACO00599) is an essential tool for researchers looking to further understand the roles and functions of CHp2 in [specific research area].Whether investigating [specific function or pathway] or exploring potential therapeutic targets, the CHp2 Antibody (PACO00599) offers researchers a reliable and accurate tool for their research needs. Trust Assay Genie for high-quality antibodies that deliver consistent and trustworthy results.
Antibody Name:
CHP2 Antibody
Antibody SKU:
PACO00599
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human CHP2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CHP2; HCA520; Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520
UniProt Protein Function:
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
UniProt Protein Details:
NCBI Summary:
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]
