The CHRM1 Polyclonal Antibody (CAB12323) is a valuable tool for researchers investigating the role of the CHRM1 receptor in various biological processes. The antibody is raised in rabbits and is highly reactive with human samples, making it a reliable choice for immunological studies.CHRM1, also known as the muscarinic acetylcholine receptor M1, is involved in mediating the effects of acetylcholine in the nervous system and other tissues. It plays a key role in regulating a variety of physiological functions, including smooth muscle contraction, cardiac function, and cognitive processes.This antibody is validated for use in Western blot applications, allowing for the detection and analysis of CHRM1 protein levels in different cell types.
Its high specificity and sensitivity make it ideal for research in neuroscience, pharmacology, and drug discovery, providing valuable insights into the function of the CHRM1 receptor and its potential as a therapeutic target in diseases like Alzheimer's and Parkinson's.Overall, the CHRM1 Polyclonal Antibody (CAB12323) is a powerful tool for researchers looking to deepen their understanding of CHRM1 biology and explore its potential implications in a wide range of physiological and pathological conditions.
Product Name:
CHRM1 Rabbit Polyclonal Antibody
SKU:
CAB12323
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-460 of human CHRM1 (NP_000729.2).
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
Purification Method:
Affinity purification
Gene ID:
1128
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHRM1 Rabbit pAb (CAB12323) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
