Description
CHSY1 Antibody (PACO00602)
The CHSY1 Polyclonal Antibody (PACO00602) is a valuable tool for researchers studying CHSY1, an enzyme involved in chondroitin sulfate biosynthesis. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.CHSY1 plays a crucial role in the production of chondroitin sulfate, a major component of extracellular matrix and cartilage. Dysregulation of CHSY1 has been linked to various diseases, including osteoarthritis and cancer. By targeting CHSY1 with this antibody, researchers can investigate the expression and activity of the enzyme in different cell types and tissues.
The ability to detect and analyze CHSY1 protein levels with this antibody makes it a valuable tool for studies in glycosaminoglycan metabolism, cartilage biology, and diseases associated with chondroitin sulfate dysregulation. Characterizing the role of CHSY1 in these pathways could lead to new insights and potential therapeutic targets for related conditions.
| Antibody Name: | CHSY1 Antibody |
| Antibody SKU: | PACO00602 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human CHSY1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CHSY1; CHSY; CSS1; KIAA0990; Chondroitin sulfate synthase 1; Chondroitin glucuronyltransferase 1; Chondroitin synthase 1; ChSy-1; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1; N-acetylgalactosa |
| UniProt Protein Function: | CHSY1: Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. Defects in CHSY1 are the cause of Temtamy preaxial brachydactyly syndrome (TPBS). A syndrome characterized by multiple congenital anomalies, mental retardation, sensorineural deafness, talon cusps of upper central incisors, growth retardation, and bilateral symmetric digital anomalies mainly in the form of preaxial brachydactyly and hyperphalangism. Belongs to the chondroitin N- acetylgalactosaminyltransferase family. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.4.1.175; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis; EC 2.4.1.226 Chromosomal Location of Human Ortholog: 15q26.3 Cellular Component: extracellular region; Golgi membrane; membrane Molecular Function:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity Biological Process: chondroitin sulfate biosynthetic process; negative regulation of ossification Disease: Temtamy Preaxial Brachydactyly Syndrome |
| NCBI Summary: | This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q86X52 |
| NCBI GenInfo Identifier: | 116241296 |
| NCBI Gene ID: | 22856 |
| NCBI Accession: | Q86X52.3 |
| UniProt Secondary Accession: | Q86X52,Q6UX38, Q7LFU5, Q9Y2J5, |
| UniProt Related Accession: | Q86X52 |
| Molecular Weight: | 91,784 Da |
| NCBI Full Name: | Chondroitin sulfate synthase 1 |
| NCBI Synonym Full Names: | chondroitin sulfate synthase 1 |
| NCBI Official Symbol: | CHSY1Â Â |
| NCBI Official Synonym Symbols: | CHSY; CSS1; TPBS; ChSy-1Â Â |
| NCBI Protein Information: | chondroitin sulfate synthase 1 |
| UniProt Protein Name: | Chondroitin sulfate synthase 1 |
| UniProt Synonym Protein Names: | Chondroitin glucuronyltransferase 1; Chondroitin synthase 1; ChSy-1; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1; N-acetylgalactosaminyltransferase 1 |
| Protein Family: | Chondroitin sulfate synthase |
| UniProt Gene Name: | CHSY1Â Â |
| UniProt Entry Name: | CHSS1_HUMAN |
