The CIART Antibody (PAC039638) is a polyclonal antibody designed for research on CIART, a key protein involved in cell growth and proliferation. This antibody, generated in rabbits, is highly specific for detecting CIART in human samples and is suitable for use in various laboratory techniques, including Western blot analysis.CIART is a crucial factor in regulating cell cycle progression and has been implicated in various cellular processes, including DNA replication and repair. Its role in promoting cell growth makes it a promising target for studies in cancer research and developmental biology.
By using the CIART Antibody, researchers can effectively study the expression and function of CIART in different cell types, contributing to a better understanding of its role in normal physiology and disease states.Overall, the CIART Antibody offers a valuable tool for investigating the biological functions of CIART and its potential implications in various cellular pathways and disease processes. Its high specificity and reliability make it a convenient choice for researchers aiming to explore the molecular mechanisms underlying cell growth and proliferation.
Antibody Name:
CIART Antibody (PACO39638)
Antibody SKU:
PACO39638
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Circadian-associated transcriptional repressor protein (1-385AA)
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO39638 at dilution of 1:100.
Background:
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
Synonyms:
Circadian-associated transcriptional repressor (ChIP-derived repressor of network oscillator) (Chrono) (Computationally highlighted repressor of the network oscillator), CIART, C1orf51
UniProt Protein Function:
CHRONO: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factorChromosomal Location of Human Ortholog: 1q21.2Cellular Component: nucleusMolecular Function: protein bindingBiological Process: circadian regulation of gene expression; locomotor rhythm; negative regulation of transcription, DNA-dependent
