The CIB2 Polyclonal Antibody (PAC048294) is a valuable tool for researchers studying the CIB2 protein, which plays a key role in auditory function and hair cell development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunofluorescence.CIB2 is a calcium- and integrin-binding protein that is essential for the proper functioning of hair cells in the inner ear. Mutations in the CIB2 gene have been linked to hearing loss and other auditory disorders, making it a promising target for further research in the field of otology.
By using this antibody to detect and analyze CIB2 expression in different cell types, researchers can deepen their understanding of the molecular mechanisms underlying hearing and balance.In conclusion, the CIB2 Polyclonal Antibody (PAC048294) is a reliable tool for investigating the role of CIB2 in auditory physiology and pathophysiology. Its specificity and sensitivity make it an ideal choice for studies focused on hearing loss, sensory perception, and inner ear development. Unlock the mysteries of CIB2 with this high-quality antibody and advance your research in the field of auditory biology.
Antibody Name:
CIB2 Antibody (PACO48294)
Antibody SKU:
PACO48294
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Calcium and integrin-binding family member 2 protein (65-164AA)
Immunofluorescent analysis of Hela cells using PACO48294 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process (By similarity).
Synonyms:
Calcium and integrin-binding family member 2 (Kinase-interacting protein 2) (KIP 2), CIB2, KIP2
UniProt Protein Function:
CIB2: Critical for proper photorecetor cell maintenance and function. May play a role in calcium homeostasis and participate in calcium regulation in the mechanotransduction processProtein type: Calcium-bindingChromosomal Location of Human Ortholog: 15q24Cellular Component: cytoplasm; photoreceptor inner segment; photoreceptor outer segment; stereociliumMolecular Function: calcium ion binding; magnesium ion binding; protein binding; protein homodimerization activityBiological Process: calcium ion homeostasis; elevation of cytosolic calcium ion concentration; photoreceptor cell maintenanceDisease: Deafness, Autosomal Recessive 48; Usher Syndrome, Type Ij
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs), and it is involved in photoreceptor cell maintenance. Mutations in this gene cause deafness, autosomal recessive, 48 (DFNB48), and also Usher syndrome 1J (USH1J). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
