The CIRH1A Antibody (CAB8593) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.CIRH1A plays a crucial role in maintaining cellular homeostasis by regulating the generation of ribosomes, which are essential for protein synthesis. Dysregulation of CIRH1A has been linked to various diseases, including cancer and developmental disorders. By targeting the CIRH1A protein, researchers can gain insight into its role in these pathological conditions and potentially identify therapeutic targets for intervention.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
CIRH1A Antibody
SKU:
CAB8593
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
NAIC, CIRH1A, CIRHIN, TEX292
Positive Sample:
U-251MG, HeLa, HT-1080, K-562, Mouse liver
Cellular Localization:
Nucleus, Nucleolus.
Calculated MW:
77kDa
Observed MW:
77kDa
This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
84916
RRID
AB_2768928
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using CIRH1A Rabbit pAb (CAB8593) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 5s.
