The CKAP2L Polyclonal Antibody (PAC04676) is designed for research involving CKAP2L, a protein known to play a role in cell division and cancer progression. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunohistochemistry. It binds specifically to the CKAP2L protein, allowing for accurate detection and analysis in a variety of cell types.CKAP2L, also known as cytoskeleton-associated protein 2-like, is involved in microtubule organization and has been implicated in the regulation of cell cycle progression.
Its role in cancer development and progression makes it a compelling target for research in oncology and cell biology. Understanding the function of CKAP2L may provide insights into potential therapeutic strategies for cancer treatment and other related diseases.Overall, the CKAP2L Polyclonal Antibody is a valuable tool for researchers studying cell division, cancer biology, and related fields. Its specificity and sensitivity make it ideal for experiments aimed at unraveling the mechanisms underlying CKAP2L function and its potential implications in disease processes.
Immunohistochemistry of paraffin-embedded human melanoma using PACO46766 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46766 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human brain tissue using PACO46766 at dilution of 1:100.
Background:
Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells.
Synonyms:
Cytoskeleton-associated protein 2-like (Radial fiber and mitotic spindle protein) (Radmis), CKAP2L
UniProt Protein Function:
CKAP2L: Belongs to the CKAP2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 2q13Cellular Component: spindle pole; centrosome; cytoplasmDisease: Filippi Syndrome
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes, and chromatin bridges. There is evidence that mutations in this gene are associated with Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial feature defects, and syndactyly. There is a pseudogene of this gene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
