The CLDN23 Polyclonal Antibody (PACO14276) is a valuable tool for researchers studying CLDN23, a member of the claudin family of proteins that are key components of tight junctions in epithelial cells. This antibody, produced in rabbits, displays high specificity and sensitivity for detecting CLDN23 in human samples, making it ideal for use in immunohistochemistry and other research applications.CLDN23 is involved in the regulation of paracellular permeability and plays a crucial role in maintaining epithelial barrier function. Dysregulation of CLDN23 has been implicated in various diseases, including cancer and gastrointestinal disorders.
By targeting CLDN23 with this antibody, researchers can gain important insights into the role of tight junction proteins in disease pathogenesis and potential therapeutic targets.Overall, the CLDN23 Polyclonal Antibody (PACO14276) offers researchers a reliable tool for studying the function and regulation of CLDN23 in health and disease. Its high reactivity and specificity make it an essential component of any research program investigating tight junction proteins and epithelial barrier function.
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO14276(CLDN23 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14276(CLDN23 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer.
Synonyms:
claudin 23
UniProt Protein Function:
Claudin-23: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell adhesionChromosomal Location of Human Ortholog: 8p23.1Cellular Component: tight junctionMolecular Function: identical protein bindingBiological Process: calcium-independent cell-cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010]
