The CLDN23 Polyclonal Antibody (PAC014277) is a valuable tool for researchers studying CLDN23, a member of the claudin protein family that plays a critical role in the tight junctions of epithelial cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.CLDN23 is involved in maintaining the barrier function of epithelial tissues, including the intestinal epithelium, and its dysregulation has been linked to various gastrointestinal disorders.
By targeting the CLDN23 protein, researchers can investigate its role in epithelial barrier function and its potential implications in diseases such as inflammatory bowel disease and colorectal cancer.With its specificity and sensitivity in detecting CLDN23, this polyclonal antibody is an essential tool for studies in epithelial biology, gastrointestinal health, and the development of new therapeutic strategies for epithelial-related diseases.
Antibody Name:
CLDN23 Antibody (PACO14277)
Antibody SKU:
PACO14277
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human CLDN23
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-5: HUVEC cells, 293T cells, mouse bladder tissue, human placenta tissue, mouse kidney tissue, Primary antibody: PACO14277(CLDN23 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
Background:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer.
Synonyms:
claudin 23
UniProt Protein Function:
Claudin-23: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell adhesionChromosomal Location of Human Ortholog: 8p23.1Cellular Component: tight junctionMolecular Function: identical protein bindingBiological Process: calcium-independent cell-cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010]
