Cleaved-MMP15 (Y132) Antibody (PACO00034)
- SKU:
- PACO00034
- Product Type:
- Antibody
- Reactivity:
- Human
- NHP - Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Cleaved-MMP15 (Y132) Antibody |
| Antibody SKU: | PACO00034 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Monkey |
| Immunogen: | synthesized peptide derived from the Internal region of human MMP-15. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MMP15; Matrix metalloproteinase-15; MMP-15; Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2 |
| UniProt Protein Function: | MMP15: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.24.-; Protease Chromosomal Location of Human Ortholog: 16q13 Cellular Component: plasma membrane Molecular Function:enzyme activator activity; protein binding; serine-type endopeptidase activity Biological Process: collagen catabolic process; extracellular matrix disassembly; protein modification process |
| NCBI Summary: | This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P51511 |
| NCBI GenInfo Identifier: | 1705988 |
| NCBI Gene ID: | 4324 |
| NCBI Accession: | P51511.1 |
| UniProt Secondary Accession: | P51511,Q14111, A0A2U6, |
| UniProt Related Accession: | P51511 |
| Molecular Weight: | 75,807 Da |
| NCBI Full Name: | Matrix metalloproteinase-15 |
| NCBI Synonym Full Names: | matrix metallopeptidase 15 |
| NCBI Official Symbol: | MMP15Â Â |
| NCBI Official Synonym Symbols: | MMP-15; MT2MMP; MTMMP2; SMCP-2; MT2-MMPÂ Â |
| NCBI Protein Information: | matrix metalloproteinase-15 |
| UniProt Protein Name: | Matrix metalloproteinase-15 |
| UniProt Synonym Protein Names: | Membrane-type matrix metalloproteinase 2; MT-MMP 2; MTMMP2; Membrane-type-2 matrix metalloproteinase; MT2-MMP; MT2MMP; SMCP-2 |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | MMP15Â Â |
| UniProt Entry Name: | MMP15_HUMAN |
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