The CLK1 Polyclonal Antibody (CAB6887) is a valuable tool for researchers studying the CLK1 protein, a key player in regulating cell cycle progression and gene expression. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for a range of applications including Western blotting.CLK1, also known as CDC2-like kinase 1, is essential for maintaining proper cellular functions by controlling the phosphorylation of proteins involved in RNA splicing and processing. Dysregulation of CLK1 activity has been linked to various diseases, including cancer and neurological disorders, highlighting the importance of studying its function in different cellular processes.
By utilizing the CLK1 Polyclonal Antibody, researchers can accurately detect and analyze CLK1 levels in various cell types, providing valuable insights into its role in disease development and progression. This antibody is a valuable tool for those working in the fields of cell biology, molecular biology, and cancer research, aiding in the advancement of knowledge and potential therapeutic strategies targeting CLK1.
Product Name:
CLK1 Rabbit Polyclonal Antibody
SKU:
CAB6887
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human CLK1 (NP_004062.2).
This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1195
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CLK1 antibody (CAB6887) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
