The CLUAP1 Polyclonal Antibody (PAC016047) is a key tool for researchers studying CLUAP1, a protein involved in cilia formation and maintenance. This antibody, produced in rabbits, is highly specific for detecting CLUAP1 in human samples and has been validated for use in Western blot applications.CLUAP1, also known as Clustered Absence of Sperm 1, plays a crucial role in the biogenesis and function of cilia, which are essential for various cellular processes such as signal transduction and cell motility. Dysregulation of cilia has been linked to a range of human diseases, including ciliopathies and certain types of cancer, making CLUAP1 an important target for investigation.
By using the CLUAP1 Polyclonal Antibody, researchers can accurately detect and analyze the expression of CLUAP1 in different cell types, allowing for a better understanding of its function in both normal and disease states. This antibody is a valuable tool for studies in cell biology, developmental biology, and disease mechanisms related to cilia dysfunction.
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16047(CLUAP1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse stomach tissue, Mouse brain tissue, Primary antibody: PACO16047(CLUAP1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16047(CLUAP1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms.
Synonyms:
clusterin associated protein 1
UniProt Protein Function:
CLUAP1: a nuclear protein commonly upregulated in colon cancers. It encodes a nuclear protein of 413 amino acids containing a coiled-coil domain. Associated with nuclear clusterin in a yeast two-hybrid system. Its expression gradually increases in the late S to G2/M phases of cell cycle and it returns to the basal level in the G0/G1 phases. RNAi suppression of this gene resulted in growth retardation in the transfected cells. Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: centrosome; cilium; intracellular membrane-bound organelle; nucleoplasmMolecular Function: protein bindingBiological Process: cilium biogenesis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
