Description
CMTM8 Antibody (PACO17945)
The CMTM8 Polyclonal Antibody (PAC017945) is a valuable tool for researchers studying the role of CMTM8 in various biological processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the CMTM8 protein, this antibody enables researchers to detect and analyze this molecule in different cell types, making it ideal for studies in immunology, cancer research, and beyond.CMTM8, a member of the CMTM protein family, has been implicated in various cellular functions, including immune regulation and tumor suppression. Its involvement in these processes makes it a promising target for further investigation in diseases such as cancer and autoimmune disorders.
By using the CMTM8 Polyclonal Antibody, researchers can gain valuable insights into the function of CMTM8 and its potential implications for therapeutic interventions.Overall, the CMTM8 Polyclonal Antibody offers researchers a reliable tool for investigating the role of CMTM8 in various biological contexts. Its high specificity and sensitivity make it an essential component of any study aiming to better understand the function of CMTM8 and its impact on human health.
| Antibody Name: | CMTM8 Antibody (PACO17945) |
| Antibody SKU: | PACO17945 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human CMTM8 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17945(CMTM8 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17945(CMTM8 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. |
| Synonyms: | CKLF-like MARVEL transmembrane domain containing 8 |
| UniProt Protein Function: | CMTM8: a widely distributed protein with four transmembrane regions and a MARVEL domain. Associates with the epidermal growth factor receptor. Transfection into several cell lines suppresses EGF-induced cell proliferation and increases the rate of receptor endocytosis. The lack of EGFR-mediated signaling induces cells to undergo apoptosis via caspase-dependent and -independent pathways. Knockdown of CMTM8 by siRNA promotes cell proliferation and delayed EGFR endocytosis. Two splice-variant human isoforms have been reproted. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: cytoplasm; extracellular space; integral to membrane; nucleoplasm Molecular Function:cytokine activity Biological Process: chemotaxis |
| NCBI Summary: | This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q8IZV2 |
| NCBI GenInfo Identifier: | 145559454 |
| NCBI Gene ID: | 152189 |
| NCBI Accession: | Q8IZV2.2 |
| UniProt Secondary Accession: | Q8IZV2,Q8IW01, A5D6I7, |
| UniProt Related Accession: | Q8IZV2 |
| Molecular Weight: | 12,739 Da |
| NCBI Full Name: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| NCBI Synonym Full Names: | CKLF like MARVEL transmembrane domain containing 8 |
| NCBI Official Symbol: | CMTM8Â Â |
| NCBI Official Synonym Symbols: | CKLFSF8; CKLFSF8-V2Â Â |
| NCBI Protein Information: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| UniProt Protein Name: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| UniProt Synonym Protein Names: | Chemokine-like factor superfamily member 8 |
| Protein Family: | CKLF-like MARVEL transmembrane domain-containing protein |
| UniProt Gene Name: | CMTM8Â Â |
| UniProt Entry Name: | CKLF8_HUMAN |
