Description
CMTM8 Antibody (PACO17946)
The CMTM8 Antibody (PAC017946) is a valuable tool for researchers studying CMTM8, a protein involved in immune regulation and cancer progression. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for Western blot applications. By binding to the CMTM8 protein, this antibody allows for detection and analysis in various cell types, making it an ideal choice for immunology and cancer research studies.CMTM8, also known as a regulator of immune response, plays a pivotal role in immune system modulation and has been implicated in the development and progression of various cancers.
Understanding the function and regulation of CMTM8 is crucial for identifying potential therapeutic targets in cancer therapy and immune-related diseases. The CMTM8 Antibody offers researchers a reliable tool for investigating the role of CMTM8 in these contexts, ultimately paving the way for new treatment strategies and interventions.
| Antibody Name: | CMTM8 Antibody (PACO17946) |
| Antibody SKU: | PACO17946 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human CMTM8 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO17946(CMTM8 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17946(CMTM8 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. |
| Synonyms: | CKLF-like MARVEL transmembrane domain containing 8 |
| UniProt Protein Function: | CMTM8: a widely distributed protein with four transmembrane regions and a MARVEL domain. Associates with the epidermal growth factor receptor. Transfection into several cell lines suppresses EGF-induced cell proliferation and increases the rate of receptor endocytosis. The lack of EGFR-mediated signaling induces cells to undergo apoptosis via caspase-dependent and -independent pathways. Knockdown of CMTM8 by siRNA promotes cell proliferation and delayed EGFR endocytosis. Two splice-variant human isoforms have been reproted. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: cytoplasm; extracellular space; integral to membrane; nucleoplasm Molecular Function:cytokine activity Biological Process: chemotaxis |
| NCBI Summary: | This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q8IZV2 |
| NCBI GenInfo Identifier: | 145559454 |
| NCBI Gene ID: | 152189 |
| NCBI Accession: | Q8IZV2.2 |
| UniProt Secondary Accession: | Q8IZV2,Q8IW01, A5D6I7, |
| UniProt Related Accession: | Q8IZV2 |
| Molecular Weight: | 12,739 Da |
| NCBI Full Name: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| NCBI Synonym Full Names: | CKLF like MARVEL transmembrane domain containing 8 |
| NCBI Official Symbol: | CMTM8Â Â |
| NCBI Official Synonym Symbols: | CKLFSF8; CKLFSF8-V2Â Â |
| NCBI Protein Information: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| UniProt Protein Name: | CKLF-like MARVEL transmembrane domain-containing protein 8 |
| UniProt Synonym Protein Names: | Chemokine-like factor superfamily member 8 |
| Protein Family: | CKLF-like MARVEL transmembrane domain-containing protein |
| UniProt Gene Name: | CMTM8Â Â |
| UniProt Entry Name: | CKLF8_HUMAN |
