The CNGA1 Polyclonal Antibody (PACO02465) is a powerful tool for research involving CNGA1, a key protein responsible for mediating the flow of ions in cells. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to CNGA1, this antibody enables accurate detection and analysis in a variety of cell types, making it an invaluable asset for studies in the fields of neuroscience, physiology, and molecular biology.CNGA1 is a crucial component of ion channels in cells, playing a vital role in sensory perception, neuronal signaling, and muscle contraction.
Understanding the function and regulation of CNGA1 is essential for unraveling the mechanisms underlying various physiological processes and diseases. Research on CNGA1 has significant implications for developing treatments for conditions such as sensory disorders, epilepsy, and cardiac arrhythmias. By utilizing the CNGA1 Polyclonal Antibody, researchers can delve deeper into the intricate workings of this protein and its impact on cellular function.
Antibody Name:
CNGA1 Antibody
Antibody SKU:
PACO02465
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human CNG-1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.CautionIt is uncertain whether Met-1 or Met-5 is the initiator.
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
