Description
CNN2 Antibody (PACO48726)
The CNN2 Polyclonal Antibody (PAC048726) is a valuable tool for researchers studying CNN2, a protein involved in smooth muscle contraction and regulation of blood pressure. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.CNN2, also known as Calponin 2, is essential for the contraction of smooth muscle cells, making it a key player in processes such as vascular tone regulation and smooth muscle cell migration. Dysregulation of CNN2 has been implicated in diseases such as hypertension and cardiovascular disorders, making it a promising target for therapeutic intervention.
The CNN2 Polyclonal Antibody binds specifically to CNN2 protein, enabling researchers to detect and analyze its expression in different tissue types and disease models. By understanding the role of CNN2 in smooth muscle function, researchers can gain insights into its potential as a therapeutic target for cardiovascular diseases and other conditions related to smooth muscle dysfunction.
| Antibody Name: | CNN2 Antibody (PACO48726) |
| Antibody SKU: | PACO48726 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Calponin-2 protein (2-309AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, Mouse liver tissue, Mouse lung tissue, Mouse kidney tissue, Mouse brain tissue, Mouse skeletal muscle tissue. All lanes: CNN2 antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 34, 30 kDa. Observed band size: 34 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO48726 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. |
| Synonyms: | Calponin-2 (Calponin H2, smooth muscle) (Neutral calponin), CNN2 |
| UniProt Protein Function: | calponin 2: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. Belongs to the calponin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoskeleton; focal adhesion; intercellular junction; membrane; stress fiber Biological Process: cytoskeleton organization and biogenesis; regulation of actin filament-based process |
| NCBI Summary: | The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q99439 |
| NCBI GenInfo Identifier: | 6226844 |
| NCBI Gene ID: | 1265 |
| NCBI Accession: | Q99439.4 |
| UniProt Secondary Accession: | Q99439,Q92578, A5D8U8, A6NFI4, D6W5X9, |
| UniProt Related Accession: | Q99439 |
| Molecular Weight: | 29,500 Da |
| NCBI Full Name: | Calponin-2 |
| NCBI Synonym Full Names: | calponin 2 |
| NCBI Official Symbol: | CNN2Â Â |
| NCBI Protein Information: | calponin-2 |
| UniProt Protein Name: | Calponin-2 |
| UniProt Synonym Protein Names: | Calponin H2, smooth muscle; Neutral calponin |
| Protein Family: | Calponin |
| UniProt Gene Name: | CNN2Â Â |
| UniProt Entry Name: | CNN2_HUMAN |
