The CNOT4 Polyclonal Antibody (PACO08494) is a valuable tool for researchers studying the CNOT4 protein, which plays a crucial role in gene regulation and mRNA degradation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the CNOT4 protein, researchers can accurately detect and analyze its presence in a variety of cell types, making it an essential component for studies in molecular biology and cancer research.CNOT4 is a key player in the control of gene expression and protein synthesis, making it a promising target for investigations into diseases like cancer, neurodegenerative disorders, and developmental abnormalities.
Understanding the function of CNOT4 can offer insights into the mechanisms underlying these conditions and may lead to the development of targeted therapies for their treatment. The CNOT4 Polyclonal Antibody provides researchers with a reliable tool for exploring the roles of CNOT4 in cellular processes and disease pathogenesis.
CNOT4: Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex. 8 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-; Ligase; Ubiquitin ligaseChromosomal Location of Human Ortholog: 7q33Cellular Component: CCR4-NOT complex; cytosolMolecular Function: protein binding; ubiquitin-protein ligase activityBiological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; poly(A) tail shortening; protein autoubiquitination
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
